Mark Gurarie is a freelance writer, editor and part-time lecturer in writing at George Washington University.
Anita Chandrasekaran, MD, Master of Public Health, certified by the Board of Internal Medicine and Rheumatology, currently works as a rheumatologist at the Hartford Healthcare Medical Group in Connecticut.
Gel-One (cross-linked hyaluronate) is a treatment option for knee osteoarthritis (OA). This is an injection that helps control related pain.
It is derived from the protein (hyaluronic acid) extracted from chicken combs or combs. The human body naturally produces this protein to lubricate joints. Its role is to restore the level of this protein.
Gel-One was first approved by the U.S. Food and Drug Administration (FDA) in 2001. It was only evaluated in a clinical trial and proved to be effective in reducing pain scores for up to 13 weeks, but other endpoints, including stiffness And physical function, no statistical difference was found with placebo.
There is no complete cure for OA. This treatment is usually only performed after trying other management methods (such as taking medication or adjusting lifestyle).
Like any medicine, Gel-One injection is not without side effects and risks. If you have OA, it is important to know as much as possible about your treatment plan.
Gel-One is suitable for knee OA, which is characterized by joint wear and tear, which causes pain. OA is the most common form of arthritis, and although it can affect anyone, it is most common in people over 65.
First, when other treatments (such as taking non-steroidal anti-inflammatory drugs (NSAID) or physical therapy) are not effective, Gel-One will be tried. Since OA is a progressive and irreversible disease, although surgery may be an option, treating it usually means controlling symptoms. This injection represents a solid add-on therapy.
Before considering Gel-One injection as a treatment, the correct diagnosis of OA is essential. How to evaluate this situation? This is a quick breakdown:
Discuss all medications, supplements, and vitamins you are currently taking with your healthcare provider. Although some drugs pose a slight risk of interaction, other drugs may be completely contraindicated or prompt to carefully consider whether the benefits and harms of treatment are greater than your case.
Hyaluronic acid derivatives sold under names such as Restylane, Juvéderm and Perlane are facial fillers used to smooth wrinkles or plump lips. Like joints, hyaluronic acid levels will decrease with age, leading to sagging skin. By injecting these into the face, the skin will become firmer.
In addition, dentists may use topical hyaluronic acid as part of a treatment plan for chronic gum inflammation. In addition to other treatments, it also helps reduce inflammation in these areas and helps treat gingivitis, periodontitis and other problems.
Gel-One injections are only administered by healthcare providers in hospital settings, and as mentioned above, it is not recommended to perform this type of treatment more than once per knee. It is packed in a pre-installed glass syringe, filled with 3 milliliters (mL) of solution, which contains 30 milligrams (mg) of hyaluronic acid.
Seigaku Corporation, which produces Gel-One, and the FDA emphasize that it is not recommended to take multiple times or change the prescription. However, if you are unsure, be sure to discuss the appropriate dosage with your doctor.
Although management and storage depend on your healthcare provider, it is important to understand what this should look like. The correct use of Gel-One is as follows:
The more common side effects of Gel-One injection tend to resolve; however, you should let your health care provider know if these problems persist or occur. They include:
After treatment, please pay attention to how you feel. If you think you need help, please don’t hesitate to ask for help.
Severe reactions to Gel-One are rare and most are caused by allergic reactions to drugs. If you encounter any of the following situations, please seek help immediately:
The reason that Gel-One is generally tolerated is that the drug is administered by a healthcare provider, thereby reducing the chance of overdose. Since it is usually not given multiple times (at least on the same knee), the possibility of a bad interaction between this medicine and other medicines you are taking is very low.
However, it is important that if your skin has been cleaned with a quaternary ammonium disinfectant, you should not receive Gel-One injections. Drugs may react to such solutions.
Casale M, Moffa A, Vella P, etc. Hyaluronic acid: the future of dentistry. system assesment. Int J Immunopathol Pharmacol. 2016;29(4):572-582.
Post time: Oct-19-2021