FRANKFURT, Germany-(BUSINESS WIRE)-Merz Therapeutics, moetapele lefapheng la neurotoxins le khoebo e tlas'a Merz Group, le Teijin Pharma Limited, k'hamphani ea mantlha ea khoebo ea bophelo bo botle ea Teijin Group, ka kopanelo ba phatlalalitse kajeno hore Teijin Pharmaceuticals e hlotse tumello ho tsoa Lefapheng la Bophelo la Japane la Bophelo, Mosebetsi le Boiketlo (MHLW) ho sebelisa Xeomin® (incobotulinumtoxinA) ka li-unit tsa 50, 100 kapa 200 tsa ente ea intramuscular bakeng sa phekolo ea li-spasms tsa maoto a tlase.
Ho otlolla maoto le matsoho a ka tlase ke sesupo sa lefu la neuron le kaholimo la koloi, le bonahatsoang haholo ke ho eketseha ha mesifa ea maoto le matsoho le thabo e feteletseng ea ho otlolla reflex e le sequelae ea stroke.Matšoao a ka sehloohong ke bothata ba ho tsamaea ka mokhoa o tloaelehileng le kotsi e eketsehileng ea ho oa ka lebaka la kutu e sa tsitsang, mesebetsi e thata kapa e sitisang bophelong ba letsatsi le letsatsi.Kalafo e tloaelehileng bakeng sa maqeba a leoto e kenyelletsa ho tsosolosa 'mele le tšebeliso ea li-retrollers tsa molomo kapa li-neuromuscular blockers, tse kang mofuta oa chefo ea botulinum A.
Stefan Brinkmann, CEO oa Merz Therapeutics, o itse: "Kamohelo e atolositsoeng e tšoaea mohato oa bohlokoa ho Merz Therapeutics mme ke litholoana tsa tšebelisano ea rona e haufi le Teijin Pharmaceuticals.Re tšepa hore balekane ba rona ba tla hlahisa sesupo sena sa bohlokoa sa ho hloka botsitso ho lingaka le bakuli ba Majapane. ”
Dr. Stefan Albrecht, Motlatsi e Moholo oa Global R&D, Merz Therapeutics: "Katoloso ena ea laibole Japane ke mohlala o mong o hlahelletseng oa melemo eo Xeomin ® e fanang ka eona ho bakuli ba bangata ba nang le spasticity kamora ho otloa ke setorouku.Hona joale lingaka li ka khetha ho alafa spasticity e tlase le e ka holimo, kapa li ka fetoha habonolo ha ho hlokahala Sebelisa litekanyetso tsa motho ka mong ka hloko.Re motlotlo ka katleho ena, haholo-holo tšebelisano-'moho e babatsehang le molekane oa rona Teijin. "
Mopresidente oa Teijin Pharmaceutical Ichiro Watanabe o itse: "Teijin Pharmaceutical e fana ka mefuta e fapaneng ea lithethefatsi, ho kenyeletsoa kalafo ea lefu la masapo le lisebelisoa tsa bongaka, joalo ka leqhubu la molumo le potlakisang mokhoa oa ho folisa fracture bakeng sa bakuli ba nang le mafu a mesifa le masapo.E le karabelo ho liphetoho tsa palo ea batho le tlhokomeliso e eketsehileng ea bophelo bo botle , Re qala lithethefatsi tse ncha tse sebetsang hantle le litharollo, ho kenyelletsa le ho phethahala ha sechaba se tsitsitseng haholoanyane.Teijin Pharmaceuticals e tsoela pele ho kenya letsoho ho ntlafatsa boleng ba bophelo (QOL) ba bakuli ka ho fana ka mekhoa e mecha ea phekolo bakeng sa mafu a nang le litlhoko tse sa finyelloang.”
Xeomin® e sebetsana ka katleho le lipheletso tsa methapo ea kutlo ea cholinergic ka ho fokolisa ho honyela ha mesifa ea boithaopo, le ho imolla tsitsipano ea mesifa ka ho thibela ho lokolloa ha neurotransmitter e bitsoang acetylcholine.Neurotoxin e hloekisitsoeng haholo ke eona feela motsoako o sebetsang ho Xeomin®.E entsoe ka ho tlosa liprotheine tse rarahaneng ho tloha mofuteng oa A botulinum chefo e hlahisoang ke Clostridium botulinum ho sebelisa theknoloji ea ho hloekisa e entsoeng ke Merz Pharma GmbH & Co. KGaA.Ho haella ha liprotheine tse rarahaneng ho lumella Xeomin® ho fokotsa tlhahiso ea li-antibodies tse ka fokotsang katleho.Ntlafatso e kholo ea palo ea plantar flexor modified ashworth scale (MAS) e ile ea bonoa tekong ea kliniki ea phase III Japane.
Xeomin® e ajoa ke Merz Pharmaceuticals GmbH linaheng tse fetang 70 'me e sebelisoa ho phekola bakuli ba nang le maoto a ka holimo a maoto, cervical dystonia, blepharospasm kapa salivation e feteletseng.Teijin Pharmaceuticals e saenetse laesense e khethehileng le tumellano e kopanetsoeng ea nts'etsopele ea Xeomin® Japane le Merz ka 2017, 'me ea qala thekiso e khethehileng ea Xeomin® ka Tšitoe 2020 ka mor'a ho fumana tumello ho tsoa Lefapheng la Bophelo bo Botle, Basebetsi le Boiketlo (MHLW) la Japane.Ho ipapisitsoe le teko ea bongaka ea Merz's Phase III Japane, litumello tse ling tse sa tsoa fumanoa li fetotse tse ling tsa litumello tse amohetsoeng.
Ka kakaretso, ho batho ba baholo, Xeomin® e lokela ho kenngoa ka har'a mesifa e mengata e thata.* Tekanyo e phahameng ka ho fetisisa ea tsamaiso ke li-unit tse 400, empa e lokela ho fokotsoa ka nepo ho isa tekanyong e tlase ho latela mofuta le palo ea mesifa ea tonic e reretsoeng.Haeba phello ea lethal dose e fetileng e fokotseha, litekanyetso tse pheta-phetoang lia lumelloa.Nako ea ho noa e lokela ho ba libeke tse 12 kapa ho feta, empa e ka khutsufatsoa ho libeke tse 10 ho latela matšoao.
* Myotonic: gastrocnemius (hlooho ea bohareng, hlooho e ka morao), soleus, posterior tibialis, flexor digitorum longus, joalo-joalo.
Merz Therapeutics ke khoebo ea Merz Pharmaceuticals GmbH e ikemiselitseng ho ntlafatsa bophelo ba bakuli lefatšeng ka bophara.Ka lipatlisiso tsa eona tse sa feleng, nts'etsopele le setso sa boqapi, Merz Therapeutics e ikitlaelletsa ho fihlela litlhoko tse sa fihlelleheng tsa bakuli le ho fumana litholoana tse ntle.Merz Therapeutics e batla ho fihlela litlhoko tse ikhethang tsa batho ba nang le mathata a ho sisinyeha, mafu a methapo ea kutlo, mafu a sebete le maemo a mang a bophelo a amang haholo bophelo ba bakuli.Merz Therapeutics e na le ntlo-khōlō Frankfurt, Jeremane, e nang le liofisi tsa baemeli linaheng tse fetang 90, le lekala la Amerika Leboea Raleigh, North Carolina.Merz Pharmaceuticals GmbH ke karolo ea Merz Group, k'hamphani e ikemetseng ea malapa e ikemiselitseng ho hlahisa mekhoa e mecha e khotsofatsang litlhoko tsa bakuli le bareki ka lilemo tse fetang 110.
Teijin (Khoutu ea Tokyo Stock Exchange: 3401) ke sehlopha sa lefats'e se tsamaisoang ke theknoloji se fanang ka tharollo e tsoetseng pele tšimong ea bohlokoa ba tikoloho;polokeho, tshireletso, le phokotso ya dikoduwa;hammoho le liphetoho tsa palo ea batho le tlhokomeliso e eketsehileng ea bophelo bo botle.Teijin e thehiloe qalong ka 1918 joalo ka moetsi oa pele oa rayon Japane, 'me hajoale e se e fetohile khoebo e ikhethileng e akaretsang libaka tse tharo tsa mantlha tsa khoebo: lisebelisoa tse sebetsang hantle tse kenyelletsang aramid, carbon fiber le lisebelisoa tse kopaneng, hammoho le resin le polasetiki, Filimi. , fiber ea polyester le ts'ebetso ea lihlahisoa;tlhokomelo ea meriana, ho kenyeletsoa meriana le lisebelisoa tsa bophelo bo botle ba malapeng bakeng sa masapo / manonyeletso, tsamaiso ea ho hema, le mafu a pelo / metabolism, booki le tlhokomelo ea pele ho matšoao;le IT, ho kenyeletsoa litharollo tsa bongaka, tsa khoebo le tsa B2B bakeng sa litsamaiso tsa sechaba, hammoho le software e pakiloeng le lits'ebeletso tsa inthanete tsa B2C bakeng sa boithabiso ba dijithale.Joalokaha ho hlalositsoe polelong ea "Human Chemistry, Human Solutions", Teijin e ikemiselitse ka botebo ho bankakarolo ba eona mme e ikemiselitse ho ba k'hamphani e tšehetsang sechaba sa ka moso.Sehlopha sena se entsoe ka lik'hamphani tse fetang 170 'me se na le basebetsi ba ka bang 20,000 linaheng / libaka tse 20 lefatšeng ka bophara.Selemong sa lichelete se qetellang ka la 31 Hlakubele 2021, Teijin o phatlalalitse thekiso e kopaneng ea li-yen tse libilione tse 836.5 (liranta tse libilione tse 7.7) le thepa eohle ea li-yen tse libilione tse 1.036.4 (liranta tse limilione tse likete tse 9.5).
Nako ea poso: Sep-10-2021